Knee osteoarthritis can make everyday movement increasingly difficult. Arthrosamid® is a single-injection hydrogel treatment designed to reduce pain and improve knee function.
At Xcel Health, we assess your symptoms, previous treatment and goals to determine whether Arthrosamid may be suitable for you.
If this sounds familiar, it may be time to explore what other treatment options are available.
Arthrosamid® is a non-surgical hydrogel injection for adults with knee osteoarthritis.
It contains 2.5% cross-linked polyacrylamide and 97.5% water. Once injected into the knee joint, the hydrogel integrates with the synovial tissue lining the joint, helping to change its mechanical properties.
The aim is to reduce osteoarthritis-related pain and improve knee function.
At a Glance:
Specifically intended for the symptomatic treatment of knee osteoarthritis.
Studies have reported sustained improvement in some patients, although individual results vary.
A single 6 ml dose is injected into the affected knee.
Treatment is carried out as an outpatient procedure.
Injection therapy may be considered for a range of joint, tendon, and nerve-related conditions where pain, stiffness, or inflammation is limiting movement or recovery.
The hydrogel is placed into the affected knee joint.
It becomes integrated with the synovial tissue
Helps reduce knee pain and improve overall joint function.
For suitable patients, Arthrosamid® may offer:
No joint replacement surgery is involved.
One 6 ml injection rather than a scheduled series.
It works differently from steroid and hyaluronic acid injection.
Research has reported sustained improvements in pain and function for some patients.
Results vary, and no treatment can guarantee a particular outcome.
Arthrosamid® may be worth discussing if:
Arthrosamid® is not suitable for everyone. Your diagnosis, symptoms, medical history and previous treatment should all be considered before treatment is recommended.
Not sure? That is what the assessment is for.
Booking an assessment does not mean committing to an injection.

Your treatment is delivered by highly experienced clinicians with expertise in advanced injection therapies.
We assess your knee, symptoms and goals before recommending whether Arthrosamid® is right for you.
Where appropriate, we combine your treatment with rehabilitation and movement support to help you get the most from your care.
You will understand the potential benefits, limitations and risks before making your decision.
Access trusted Arthrosamid® treatment and ongoing support across seven Xcel Health clinics.
Response times vary. Some patients may notice changes within the first few weeks, while improvement may develop more gradually for others.
Response times vary. Some patients may notice changes within the first few weeks, while improvement may develop more gradually for others.
Your clinician will provide personalised guidance about activity and aftercare following the procedure.
| Arthrosamid® | Steroid injection | Hyaluronic acid | |
|---|---|---|---|
| Treatment | Polyacrylamide hydrogel | Corticosteroid | Naturally-derived lubricant |
| How it works | Integrates with synovial tissue for mechanical support | Reduces local inflammation | Supplements joint lubrication |
| Procedure | Single 6ml injection | Injection, may be repeated | Course of injections, often 1–3 |
| Approach | Designed to remain in the joint long-term | Short-term anti-inflammatory effect | Gradually absorbed by the body |
| Expected Duration | Long-term potential from a single treatment* | Weeks to a few months | A few months |
*Individual results vary and no treatment can guarantee a particular outcome.
Access knee osteoarthritis assessment and care across the Xcel Health clinic network. Availability may vary by clinic.
As with any injection procedure, side effects can occur.
Reported effects may include:
Temporary pain or discomfort
Swelling around the treated knee
Joint stiffness
A feeling of fullness or pressure
There are also risks associated with any injection into a joint, including infection.
Your clinician will discuss the potential risks, precautions and warning signs before treatment. If you experience severe, worsening or concerning symptoms afterwards, contact your treating clinical team promptly.
Then we will tell you. An assessment at Xcel Health is not a commitment to have an injection.
If Arthrosamid® is not the right option, we will explain why and discuss suitable alternatives.
The first step is not an injection it is a clinical conversation about your knee.
This information is for general educational purposes and does not replace individual medical advice, diagnosis or treatment. Suitability for Arthrosamid® must be determined by an appropriately qualified healthcare professional. Results vary between individuals.